sequential integration for different levels of data #6
Description
The second computation is sequential integration for different levels of data. DOCKET Integrate will implement statistical models to extract the underlying association or knowledge by integration of two different levels of data. For example, when considering which gene mutations are associated with differential knockdown efficacy of RAS in lung adenocarcinoma (LUAD), DOCKET Integrate will select gene knockdown data of LUAD cell lines from DepMap, merge the gene mutation data of the same cell lines from CCLE, build regression models and perform hypothesis testing to generate gene pairs and p-values to add to the TKG.