diff --git a/src/prebuilt/wasm2c_simd_source_declarations.cc b/src/prebuilt/wasm2c_simd_source_declarations.cc
index a43a000696..0089a0cac5 100644
--- a/src/prebuilt/wasm2c_simd_source_declarations.cc
+++ b/src/prebuilt/wasm2c_simd_source_declarations.cc
@@ -1,4 +1,6 @@
-const char* s_simd_source_declarations = R"w2c_template(#if defined(__GNUC__) && defined(__x86_64__)
+const char* s_simd_source_declarations = R"w2c_template(#if WASM_RT_MEMCHECK_GUARD_PAGES
+)w2c_template"
+R"w2c_template(#if defined(__GNUC__) && defined(__x86_64__)
 )w2c_template"
 R"w2c_template(#define SIMD_FORCE_READ(var) __asm__("" ::"x"(var));
 )w2c_template"
@@ -8,6 +10,14 @@ R"w2c_template(#define SIMD_FORCE_READ(var) __asm__("" ::"w"(var));
 )w2c_template"
 R"w2c_template(#else
 )w2c_template"
+R"w2c_template(// best-effort using volatile
+)w2c_template"
+R"w2c_template(#define SIMD_FORCE_READ(var) (void)*(volatile v128*)&var;
+)w2c_template"
+R"w2c_template(#endif
+)w2c_template"
+R"w2c_template(#else
+)w2c_template"
 R"w2c_template(#define SIMD_FORCE_READ(var)
 )w2c_template"
 R"w2c_template(#endif
diff --git a/src/template/wasm2c_simd.declarations.c b/src/template/wasm2c_simd.declarations.c
index 39eb4578e1..8e16c1c4be 100644
--- a/src/template/wasm2c_simd.declarations.c
+++ b/src/template/wasm2c_simd.declarations.c
@@ -1,8 +1,13 @@
+#if WASM_RT_MEMCHECK_GUARD_PAGES
 #if defined(__GNUC__) && defined(__x86_64__)
 #define SIMD_FORCE_READ(var) __asm__("" ::"x"(var));
 #elif defined(__GNUC__) && defined(__aarch64__)
 #define SIMD_FORCE_READ(var) __asm__("" ::"w"(var));
 #else
+// best-effort using volatile
+#define SIMD_FORCE_READ(var) (void)*(volatile v128*)&var;
+#endif
+#else
 #define SIMD_FORCE_READ(var)
 #endif
 // TODO: equivalent constraint for ARM and other architectures